For the aim of general Anesthesiaduring surgeries, many artificial neurosteroids have been used as analgesics.Alphaxolone, alphadolone, hydroxydione, and minaxolone are the most well-knownof them. The esterified 21-hydroxy derivative of 5-pregnanedione, hydroxydione,was the first of these to be introduced. Hydroxydioneproved to be a helpful narcotic prescription with a good safety profile, but itwas painful and worrisome to implant due to weak water solubility. Thisprepared the path for novel neuroactive steroids to emerge. Althesin, a mixtureof alphaxolone and alphadolone, was the accompanying medicine from this classto be advanced.
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